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Objective:To evaluate association of peripheral blood brain-derived neurotrophic factor (BDNF) with Alzheimer's disease (AD) .Methods:Databases including Pubmed, Cochrane library, Web of science, Embase, China National Knowledge Infrastructure, CBM disc, VIP-CSTJ and Wanfang Data were used to collect case-control studies related to the concentration of BDNF in peripheral blood of dementia patients with Alzheimer's type(DAT) and mild cognitive impairment(MCI). After extracting data and appraising the quality of the included studies, meta-analysis were conducted using Review Manager 5.3 and CMA 3.0.Results:A total of 51 articles were included in the analysis, with a total subjects of 7 182, including 2 673 subjects in DAT group, 1 506 subjects in MCI group, and 3 003 subjects in control group.The Meta-analysis showed that the levels of peripheral blood BDNF in patients with DAT were significantly lower than normal control group(SMD=-0.71, 95% CI : -0.99--0.43, P<0.001) ( n=5 111), and there were no statistical differences in peripheral blood BDNF levels between MCI group and control group and between DAT group and MCI group.The subgroup analysis showed that the level of serum BDNF in patients with DAT (SMD=-0.85, 95% CI: -1.15--0.55, P<0.001)( n=4 425) and MCI(SMD=-0.38, 95% CI: -0.62--0.14, P=0.002)( n=2 476) was significantly lower than that in normal control group, and the level of serum BDNF (SMD=-0.76, 95% CI: -1.37--0.16), P=0.01)( n=1 630) in patients with DAT was lower than that in MCI; However, there were no statistical difference among DAT, MCI and control groups in the level of plasma BDNF( P>0.05). Conclusion:The patients with DAT and mild cognitive impairment have lower level of serum BDNF, which suggesting that serum BDNF level may be a potential biomarker for early diagnosis of AD.
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Objective:To investigate the mechanism of subjective cognitive decline(SCD)in resting-state by using regional homogeneity(ReHo)and functional connectivity(FC)in SCD patients.Methods:Resting-state functional magnetic resonance imaging(RS-fMRI)was performed in 25 SCD patients and 30 normal controls matched by sex, education and nationality.DPARSFA2.3 and SPM8 software were used to analyze and screen the brain areas with abnormal ReHo values in SCD group, with the posterior cingulated(PCC)/paruneus as seed points for whole-brain FC analysis.Results:Compared with the normal control group, the SCD group showed that ReHo values of right occipital gyrus and left precuneus were increased, and ReHo values of right inferior temporal gyrus, right orbital inferior frontal gyrus and bilateral thalamus were decreased(Voxel level, Alphasim correction, P<0.05). Using PCC/ precuneus as seed voxels, the whole brain functional connectivity analysis showed that the functional connectivity with cerebelum Crus 2 R was increased, and the functional connectivity with right orbital inferior frontal gyrus, left inferior temporal gyrus and temporal pole was reduced(Voxel level, Alphasim correction, all P<0.05). Conclusions:Default mode network may play an important role in the mechanism of SCD, and abnormalities in brain areas may first occur in PCC/precuneus.
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Objective:To investigate regional homogeneity(ReHo)and whole brain functional connectivity(FC)in patients with mild cognitive impairment(MCI), and to explore the mechanisms of MCI in the resting state.Methods:Resting-state functional magnetic resonance imaging(RS-fMRI)was performed on 24 patients with MCI and 30 age, gender and nationality-matched normal controls.Abnormal brain areas in the MCI group were screened and analyzed by using the DPARSFA2.3 and SPM8 software programs.Whole brain FC analysis was performed with the posterior cingulate cortex(PCC)/precuneus as the seed points.Results:Compared with the control group, MCI subjects displayed higher ReHo values in the frontal-middle-Left, precentral-Left, postcentral-Left, rolandic-opercular-Left, and frontal-inferior-opercular-Left and lower ReHo values in the temporal-superior-right, temporal-middle-right, postcentral-right, and temporal -pole -superior -right(Voxel level, Alphasim correction, P<0.05). Whole brain FC analysis showed greater functional connectivity of PCC/precuneus with fusiform-right, thalamus-right, lingual-right and parahippocampal-right in subjects with MCI, and less functional connectivity of the PCC/precuneus with temporal-middle-Left, angular-Left, temporal-superior-Left and occipital-middle-Left in subjects with MCI(Voxel level, Alphasim correction, P<0.05). Conclusions:Abnormalities of the default mode network may be associated with the onset of MCI, and abnormalities in posterior cingulate/precuneus connectivity may be helpful in finding imaging evidence with high sensitivity to MCI.
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Objective:To develop the screening checklist of brief interview for autism disorder suitable for Chinese children and evaluate its reliability and validity.Methods:Based on existed research results and diagnostic criteria for autism spectrum disorder of DSM-5, the screening checklist of brief interview for autism spectrum disorder(SCAD) was developed. A sample of 238 children were selected for investigation and 28 of them were retested for test-retest reliability with 2-4 weeks interval. Cronbach's α coefficient, split-half correlation coefficient, test-retest reliability, and evaluator consistency were used to test the reliability of the scale. Content validity, construct validity and empirical validity were used to test the validity of the scale.All statistical analysis were conducted by SPSS 22.0 and AMOS 17.0.Results:The SCAD contains two components and six dimensions, with a total of 25 items. The Cronbach's α coefficient was 0.936 for the total scale and were 0.938, 0.771 for the two components. The split-half coefficient for the total scale and the two components were 0.962, 0.938 and 0.794. The test-retest reliability for the total scale and the two components were 0.806, 0.795 and 0.766. The Kendall coefficient for the total scale and the two components were 0.968, 0.982 and 0.950. The SCAD item-level content validity index (I-CVI) ranged from 0.66 to 0.98 and the Kappa value ranged from 0.66 to 0.98. The scale-level content validity S-CVI/UA and S-CVI/Ave were 0.89 and 0.94. The correlations between SCAD and calibration tests such as ABC, CARS and M-CHAT were 0.54, 0.53 and 0.87, and the correlation coefficients with the M-CHAT-R/F between the two components were 0.87 and 0.76 respectively (both P<0.01). The result of CFA demonstrated that the model fitted the data with well construct validity(χ 2/ df=0.910, RMR=0.049, AGFI=0.974, RMSEA=0.010, PNFI=0.530, PCFI=0.533, NFI=0.994, RFI=0.988, CFI=1.000). The correlation coefficient of the two components was 0.88 and that with the total scale were 0.97 and 0.90, each dimensions with the total scale ranged from 0.72 to 0.93. Conclusion:The SCAD has a good reliability and validity, and it can be used as a clinical screening tool for children with autism spectrum disorder.
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Objective:To verify the validity of the clinical dementia rating(CDR) for early screening of Alzheimer's disease in the community.Methods:One thousand two hundred and eighty-one community volunteers (580 males and 701 females) came to hospital for clinical interviews, laboratory tests and a series of psychological assessment, including CDR, brief elderly cognitive screening inventory (BECSI), quickly cognitive screening scale for elderly (QCSS-E), mini-mental state examination (MMSE) and core neurocognitive test (CNT). According to clinical interview, assessment and DSM-5 criteria, 623 normal cognition, 570 mild cognitive impairment (MCI) and 88 dementia with Alzheimer's type (DAT) were screened.Results:(1) The results of CDR-global scores (CDR-GS)in the community volunteers showed that 506 (39.5%) scored 0, 688 (53.7%) scored 0.5, 72 (5.6%) scored 1, and 15 (1.2%) scored 2 or more.(2) There were significantly differences on the BECSI score, QCSS-E score, MMSE score and CNT score among people with different CDR-GS ( P<0.01). In the total or dementia sample, CDR-sum of box score (CDR-SB) and CDR-GS were significantly correlated with BECSI score ( r=0.577-0.639), QCSS-E score ( r=-0.586--0.680), MMSE score ( r=-0.570--0.764) and CNT score ( r=-0.244--0.357)( P<0.01). (3) The accuracy (95.8%) and specificity (99.8%) of the CDR-GS screening DAT were slightly higher than those of the CDR-SB(91.1%, 92.0%), and its sensitivity (65.9%) was lower than that of CDR-SB(82.5%). The accuracy (72.6%), sensitivity (81.9%) and specificity (64.0%)of the CDR-GS were close to those of CDR-SB(72.1%, 83.3%, and 61.8% respectively) in screening MCI. Conclusion:The CDR can be used for screening of AD in community populations.CDR-GS and CDR-SB have their own advantages, and combination of both advantages can improve the screening efficiency.
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Objective@#To verify the criteria validity and effectiveness of the QCSS-E for screening of mild cognitive impairment (MCI) and early dementia with Alzheimer's type (DAT) among the elderly in community.@*Methods@#With stratified convenient sampling, 1 298 elderly aged 55 and over recruited from Wuxi community, who finished the clinical interviews, laboratory examination and psychological tests such as QCSS-E, ADL, MMSE, ADAS-cog, CDR, and Core Neuropsychological Test.Then they were divided into health control group(HC), MCI group and DAT group by the diagnostic criteria of Peterson’s MCI and DSM-5 AD dementia.The criteria validity and screening efficacy of QCSS-E were verified and the optimal cut off value for detecting MCI and DAT were explored.@*Results@#There were statistically significant differences in age, education level, marital status, family structure, occupation, and scores of MMSE, ADAS-cog, CNT, and QCSS-E total score and domain scores among three groups (all P<0.01). The total score and every domains score of QCSS-E were significantly correlated with test scores such as MMSE, ADAS-cog and CNT (all P<0.01). Using the total QCSS-E score to discriminate MCI from health control, the area under the curve (AUC) was 83.5%. When the cut off value was 74.5, the accuracy rate of classification was the highest (75.0%). Using the total QCSS-E score to discriminate DAT from health control, the AUC was 83.5%. When the cut off value was 64.5, the accuracy rate of classification was the highest (94.2%).@*Conclusion@#The QCSS-E has better criteria validity and higher effectiveness in screening MCI and DAT.
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Objective@#To investigate the neurocognitive characteristics and related factors in the elderly with subjective cognitive decline.@*Methods@#Among the 1 850 elderly volunteers aged over 50, 377 cognitive normal elderly (NC group), 234 subjective cognitive decline (SCD Group) and 291 patients with mild cognitive impairment (aMCI Group) were screened with the brief elderly cognitive screening questionnaire and the elderly rapid cognitive screening scale.They were all received clinical interview and examination and core neurocognitive test.@*Results@#(1) There were statistically significant differences in the three groups on the age, education, occupation, HAMD, low density lipoprotein and blood pressure (P<0.01). (2) The score of the picture-symbol association in SCD group(8.94±4.05)was lower than that in NC group(9.83±4.18)and higher than that in aMCI group (7.12±4.17)(all P<0.05), while the scores of the other neuropsychological tests were higher than those in aMCI group.There were no statistically significant difference between SCD group and NC group on the other neuropsychological tests(P>0.05). (3)The SCD was mainly influenced by age(β=0.063, OR=1.065, 95%CI=1.033-1.099), depression(β=0.182, OR=1.199, 95%CI=1.084-1.327)and hypertension(β=0.473, OR=1.604, 95%CI=1.185-2.171)(all P<0.01). And the aMCI was mainly influenced by age(β=0.078, OR=1.081, 95%CI=1.048-1.115), education(β=-0.174, OR=0.840, 95%CI=0.778-0.907), occupation(β=-0.406, OR=0.666, 95%CI=0.535-0.830)and low density lipoprotein(β=-0.451, OR=0.637, 95%CI=0.497-0.816)(all P<0.01 ).@*Conclusion@#Objective neurocognitive function of the elderly with subjective cognitive decline is basically normal.Age, depression and hypertension are risk factors of subjective cognitive decline.
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Objective To verify the criteria validity and effectiveness of the QCSS-E for screening of mild cognitive impairment (MCI) and early dementia with Alzheimer's type (DAT) among the elderly in community. Methods With stratified convenient sampling,1 298 elderly aged 55 and over recruited from Wuxi community,who finished the clinical interviews,laboratory examination and psychological tests such as QCSS-E,ADL, MMSE, ADAS-cog, CDR, and Core Neuropsychological Test. Then they were divided into health control group( HC),MCI group and DAT group by the diagnostic criteria of Peterson’s MCI and DSM-5 AD dementia. The criteria validity and screening efficacy of QCSS-E were verified and the optimal cut off value for detecting MCI and DAT were explored. Results There were statistically significant differences in age,education level,marital status,family structure,occupation,and scores of MMSE,ADAS-cog,CNT,and QCSS-E total score and domain scores among three groups (all P<0. 01). The total score and every domains score of QCSS-E were significantly correlated with test scores such as MMSE,ADAS-cog and CNT (all P<0. 01). Using the total QCSS-E score to discriminate MCI from health control,the area under the curve (AUC) was 83. 5%. When the cut off value was 74. 5,the accuracy rate of classification was the highest (75. 0%). Using the total QCSS-E score to discriminate DAT from health control,the AUC was 83. 5%. When the cut off value was 64. 5,the accuracy rate of classification was the highest (94. 2%). Conclusion The QCSS-E has better criteria validity and higher effectiveness in screening MCI and DAT.
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Objective To investigate the neurocognitive characteristics and related factors in the elderly with subjective cognitive decline. Methods Among the 1 850 elderly volunteers aged over 50,377 cognitive normal elderly (NC group),234 subjective cognitive decline ( SCD Group) and 291 patients with mild cognitive impairment (aMCI Group) were screened with the brief elderly cognitive screening question-naire and the elderly rapid cognitive screening scale. They were all received clinical interview and examina-tion and core neurocognitive test. Results ( 1) There were statistically significant differences in the three groups on the age,education,occupation,HAMD,low density lipoprotein and blood pressure (P<0. 01). (2) The score of the picture-symbol association in SCD group( 8. 94 ± 4. 05) was lower than that in NC group (9. 83±4. 18)and higher than that in aMCI group (7. 12±4. 17)(all P<0. 05),while the scores of the other neuropsychological tests were higher than those in aMCI group. There were no statistically significant differ-ence between SCD group and NC group on the other neuropsychological tests(P>0. 05). (3) The SCD was mainly influenced by age( β=0. 063, OR=1. 065,95% CI=1. 033-1. 099), depression ( β=0. 182,OR=1. 199,95%CI=1. 084-1. 327) and hypertension(β=0. 473,OR=1. 604,95% CI=1. 185-2. 171) ( all P<0. 01). And the aMCI was mainly influenced by age(β=0. 078,OR=1. 081,95%CI=1. 048-1. 115),educa-tion(β=-0. 174,OR=0. 840,95%CI=0. 778-0. 907),occupation( β=-0. 406,OR=0. 666,95%CI=0. 535-0. 830)and low density lipoprotein(β=-0. 451,OR=0. 637,95%CI=0. 497-0. 816)(all P<0. 01 ). Conclu-sion Objective neurocognitive function of the elderly with subjective cognitive decline is basically normal. Age,depression and hypertension are risk factors of subjective cognitive decline.
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Objective To develop anxiety scale suitable for Chinese pregnant women and evaluate its reliability and validity. Methods Based on existing research results and clinical experience,this study compiled pregnancy anxiety scale(PAS). A sample of 509 pregnant women were selected for investigation and 65 of them were randomly retested for test-retest reliability with 2 week interval. Item analysis was con-ducted to screen valid items. Then the construct validity of the scale was tested by exploratory factor analysis ( EFA) and confirmatory factor analysis(CFA). Finally the reliability and criterion validity of the scale were evaluated using Cronbach's α coefficient,retest reliability coefficient and Pearson correlation coefficient. Re-sults The PAS was composed of 27 items in four factors,including worry about delivery,worry about them-selves,worry about fetal health and general anxiety. The four factors were extracted by EFA which could ex-plain 62. 48% of the total variance. Besides,the result of CFA demonstrated that the model fitted the data with well construct validity (χ2/df=1. 89,RMR=0. 04,RMSEA=0. 06,IFI=0. 92,TLI=0. 91,CFI=0. 92, PGFI=0. 70,PNFI=0. 74,PCFI=0. 81). The score of the pregnancy-related anxiety scale and its factors scores were positively correlated with the scores of pregnancy-related anxiety questionnaire(PAQ) and child-birth attitudes questionnaire(CAQ). The correlation coefficients were 0. 60-0. 80 and 0. 50-0. 78 respectively (all P<0. 01). The Cronbach's α coefficient was 0. 93 for the total scale and that of the four factors ranged from 0. 82 to 0. 90. The test-retest reliability was 0. 68 for the total scale and ranged from 0. 54 to 0. 75 for the four factors. Conclusion The PAS has a good reliability and validity,and it can be used as a valid tool to measure the anxiety level of pregnant women.
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Objective To investigate the the association between psychological behavior and self-awareness of obese children and family factors,in order to provide scientific basis for clinical intervention in obese children. Methods Fifty children with obesity ( obesity group) and fifty healthy children ( control group) were included in the study. All children were evaluated with the Achenbach Child Behavior Checklist (CBCL),Piers-Harris Child's self-concept Scale ( PHCSS), Family Environment Scale-Chinese Version ( FES-CV) and Egma Minnen av Bardndosnauppforstran(EMBU). Moreover,correlation analysis was applied in the study to explore family factors affecting behavioral problems and self-awareness of obese children. Re-sults Compared with control group,significant higher ratio of abnormal behaviors was found in children with obesity (P<0. 05). FES-CV showed that the degree of expressiveness((3. 16±1. 93),(4. 65±1. 02)),intel-lectual-cultural orientation((5. 31±1. 28),(6. 10±1. 83)) and active-recreational((2. 78±1. 36),(4. 84± 1. 72)) were lower than control group,and the degree of family conflict((4. 11±1. 45),(3. 32±1. 27)) and control((6. 42±1. 37),(5. 09±1. 65)) were higher in children with obesity (P<0. 05). Moreover,EMBU showed that emotional warmth score was significantly lower in obese group than that in control group (P<0. 01),and the scores of parent's rejection,father's severity,parent's over-interference,and mother's over-protection were significantly higher than the scores in control group(P<0. 05). In obese group,the correlation analyses showed a negative association between social withdrawal in children's behavioral problems and fami-ly expressiveness (r=-0. 62,P<0. 01),and a positive association between aggressivity and family conflict (r=0. 39,P<0. 05). There was a positive correlation between internalizing behavioral problems and mother's over-protection and over-interference(r=0. 60,P<0. 01). Low self-awareness was positive associated with parent's rejection and father's severity(r=0. 46,0. 51,0. 44 respectively,P<0. 05). Conclusion A signifi-cant higher risk of abnormal psychological behaviors and low self-concept can be found in children with obe-sity,which can closely related to family factors.
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Objective To evaluate the association of peripheral blood inflammatory cytokines with mild cognitive impairment ( MCI) . Methods Databases including Pubmed,Cochrane library,Ovid,Web of science,CNKI,CBM,VIP and Wan Fang were retrieved to collect case-control studies related to the concen-tration of inflammatory cytokines in peripheral blood of MCI. After extracting data and appraising the quality of the included studies,meta-analysis were conducted using RevMan 5. 3 and CMA 3. 0. Results The lev-els of CRP,TNF-α,IL-1,MCP-1 and M-CSF and other 9 kinds of inflammatory factors in 33 studies were in-cluded in the analysis. A total of 8742 subjects were enrolled,including 2398 patients and 6344 controls. The Meta-analysis showed that the levels of CRP (SMD=0. 87,95％CI (0. 48,1. 26),P<0. 0001),TNF-α(SMD=1. 16,95％CI (0. 32,2. 00),P=0. 007),IL-1β (SMD=0. 96,95％CI (0. 17,1. 76),P=0. 02),IL-6 (SMD=1. 07, 95％CI (0. 53,1. 61),P<0. 0001),IL-8 (SMD=1. 65,95％CI (0. 36,2. 93),P=0. 01) in peripheral blood of pa-tients with MCI were significantly higher than that of normal control group;however,there was no statistical differ-ence between the two groups in the levels of IL-10,IL-12,MCP-1 and M-CSF. Conclusion The patients with MCI has a higher levels of CRP,TNF-α,IL-1β,IL-6 and IL-8 in peripheral blood,which suggesting that these in-flammatory factors may be related to the occurrence and development of AD.
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Objective To investigate the comprehensive effect and impact path of family environment,rearing style and personality on adolescents with mental disorder.Methods A sample of 200 adolescents with mental disorders and 228 normal adolescents were tested with Family Environment Scale (FESCV),Family Upbringing Style Questionnaire (FUSO),Big Five Personality Questionnaire (NEO-FFI-R) and Psychological Symptom Inventory-100(PSI-I00).Regression analysis and path analysis were used to explore influence and path of rearing style,family environment and personality on mental health.Results The total score PSI-100 in case group (204.0±68.6) was higher than that in control group (146.9±38.4)(t=10.43,P＜0.01).Regression analysis revealed that mental health was affected by rearing style (R2 =0.208) such as mother supervision-control (β =-0.249),father understands-blame (β =-0.195),mother warmth-wildness (β=-0.228) and mother acceptance-rejection (β=0.201),family environment (R2 =0.244) such as conflict (β=0.309),organization (β=-0.196) and expressiveness (β=-0.141),and personality traits (R2 =0.452)such as neuroticism (β=0.412),agreeableness (β=-0.237) and conscientiousness (β=-0.203).Path Analysis showed that personality traits directly affected mental health (β=-0.90),parenting style indirectly influenced mental health (β=0.51) by personality,the family environment had direct (β=0.20) and indirect (β=0.72) effects on mental health,and the model fits well (x2/df =2.160,RMSEA =0.052,GFI =0.88,AGFI =0.84,PGFI =0.67,NFI =0.91,RFI =0.89,IFI =0.95,TLI =0.94,CFI =0.95),and three factors explained 61％ of variation on symptom total score.Conclusion The family environment,family upbringing style and personality traits have significant effect on the adolescent's mental disorder.The personality traits are the most important variables affecting mental health family upbringing style affect mental health indirectly through personality traits,and family environment directly and indirectly affected on the mental health.
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Objective To explore the memory function and the effects of sleep on memory consolidation in patients with stable paranoid schizophrenia.Method Sixty patients with stable paranoid schizophrenia were randomly assigned into research group (n =30) and control group (n =30).30 healthy people were raised as a healthy control group.The polysomnography (PSG) was used for 10 hours of sleep monitoring in the research group and the healthy control group and the muhiple memory assessment scale(MMAS) was used to test the subjects memory before and after the sleep monitoring.Control group performed memory tests in equal length daytime.Pre-test and post-memory measurements were compared.Results The prememory test of three groups had significant statistical differences (F(2.87) =31.40,39.89;P＜0.01).Both the auditory verbal/picture memory conservation rate and recognition accuracy rate between research group and healthy controls had no statistically significance differences (P＞0.05).But compared with the control group,auditory verbal memory conservation rate ((62.64±9.06) ％ vs (43.00±9.73) ％,P＜0.01),recognition accuracy rate ((69.11±11.04)％ vs (61.78±11.67)％,P＜0.05),picture memory conservation rate((71.20±14.95) ％ vs (58.72 ± 16.19) ％,P＜ 0.01),recognition accuracy rate ((86.89 ± 8.02) ％ vs (78.89 ±12.63) ％,P＜0.01) of the research group showed statistical significance differences (P＜0.05).Both N2 (r=0.377,P＜0.05) and REM (r=0.436,P＜0.05) had positive correlation with recognition accuracy rate of auditory verbal memory in research group.Conclusion Stable paranoid schizophrenic patients have poorer memory function(auditory verbal words memory recall,picture memory recall) than healthy people.Sleep promotes the consolidation of memory in patients with schizophrenia.Both N2 and REM of patients with stable paranoid schizophrenic have positive correlation with recognition accuracy rate of auditory verbal memory.
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Objective To explore family environment,parenting style,and personality of the patients with internalizing and externalizing mental disorders.Methods 137 adolescents with internalizing mental disorder(IMD),63 adolescents with externalizing mental disorder(EMD) and 228 normal subjects (control group) were investigated with Family Environment Scale-Chinese Version (FES-CV),Family Upbringing Style Questionnaire (FUSQ) and the NEO Five Factor Inventory (NEO-FFI).Results (1) The IMD group scored significantly lower on the cohesion (6.17 ± 2.68),active recreational orientation (3.84 ±2.50),moral-religious emphasis (4.48± 1.65),organization (5.35±2.30),expressiveness (4.60±2.00),achievement orientation (5.31 ± 1.84),and higher on the conflict (4.01 ± 2.38) than control group (P＜ 0.05).The EMD group scored only higher on the conflict (4.01±2.38) than control group (P＜0.05).(2) The all dimensional scores(apart from the parent's expect-demanding) of the IMD group were significantly lower than that of control group on the FUSQ (P＜0.05).The scores on the mother's democracy-authoritarian,parent care-protect,catholic-indulgences,parental-control,and expect-demanding were significantly lower in the EMD group than those in the control group (P＜0.05).(3) Relative to the control group,the IMD group got lower scores on the agreeableness (42.02±5.01),conscientiousness (38.91±8.01),and extraversion (35.17±8.57),and higher score on the neuroticism (40.10±8.55);the EMD group got lower scores on the agreeableness(42.75±5.12),conscientiousness (39.95±8.27) and openness (40.00±6.75).Conclusion Adolescents with mental disorders are living in conflict and discord family environment,feel more negative parenting such as authoritarian,harsh,indulgence,control,and demanding,and show some unhealthy personality such as low agreeableness,low conscientiousness,and high neurotic.
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Objective To investigate changes of family parenting styles after the reforn and opening in China and its influence on mental health.Methods On the base of stratified convenience sampling,a valid sample of 429 were recruited from Wuxi and Hefei city residents:1960s group 103 persons,1970s group 107 persons,1980s group 116 persons,and 1990s group 103 persons.Subjects' childhood parenting styles were surveyed with the family upbringing style questionnaire(FUSQ) and their current mental health status was rated with the psychological symptom inventory-100 (PSI-100).Results (1) Except understanding-blame,and expects-demanding,and mother respect-humiliation and mother warmth-wildness,there were significant age differences on other parenting styles (P＜ 0.05),their scores were gradually increased from 1960s group ((38.29± 6.30)-(44.99± 7.36)) to 1980s group ((40.96±6.05)-(48.53±7.91)),1990s group declined((40.13±7.27)-(46.97±6.61)).(2) Most parenting style dimensions were significantly negatively correlated with symptom total score (r=0.095-0.308) and mental symptom scores (r=0.090-0.330).(3) The family parenting styles had significantly effects on the symptom total score (explained variance of 20.3％) and mental symptom scores (explained variance of 12.4％-21.5％).Conclusion There have been some positive,open and scientific changes on the family parenting styles after the reform and opening in China,childhood family parenting styles have long-term effects on mental health of youth and adult.
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Objective To investigate the characteristics of quality of life (QoL) and self-awareness in girls with idiopathic central precocious puberty (ICPP) and the correlation between QoL and the self-awareness.Methods The inventory of subjective life quality (ISLQ) and Children's self-concept scale (PHCSS) were employed to evaluate the level of QoL and self-awareness in 24 ICPP girls with ICPP (ICPP group) and 24 normal control girls (control group),and the correlation analysis between QoL and the self-awareness in the ICPP group was made.Results The score of overall (70.85±14.11 vs 80.21±6.07) and emotion component satisfaction (62.61± 12.91 vs 73.74±5.02),dimensions satisfaction on school life (5.80± 1.44 vs 6.69±0.65),depression experience (6.55± 1.14 vs 7.29±0.45),anxiety experience (5.93± 1.35 vs 6.96±0.82) and physical emotion (6.33±1.17 vs 7.12±0.83) in ICPP group was respectively lower than control group (P＜0.05).There was no difference in cognitive component between control group and ICPP group,as well as for other dimension satisfaction.Moreover,the score in total self-awareness,physical appearance and anxiety in ICPP group was respectively lower than those in control group (P＜0.05).In addition,a positive correlation was found between the subjective QoL and the children self-concept in ICPP group (P＜0.01).Conclusion The girls with ICPP show a lower subjective QoL and self assessment than normal girls.It is important to take care of the psychological feature of the girls with ICPP to improve the self-assessment and overall QoL during the medication.
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Objective To explore the relationship between college students' psychological health status,family parenting styles and personality characteristics using the structural equation model.Methods A total of 4 866 College students (2 122 males,2 744 females) were surveyed with NEO five-factor inventory (NEO-FFI),family upbringing style questionnaire(FUSQ) and psychological symptom inventory-100(PSI-100).Lisrel 8.7 was used to construct the structural equation model.Results NEO-FFI total score was 198.08±15.31,PSI-100 total score was 167.08±68.23,father upbringing style questionnaire total score was 457.80±62.10,and mother upbringing style questionnaire total score was 459.27±61.91.For the factors of personality,the more influential factors were agreeableness,conscientiousness and openness.There was a negative correlation between good personality and psychological symptoms(path coefficient =-0.73,P＜0.05).For the factors of family parenting styles,parenting dimension scores (such as mother's democracy,encouragement,understanding,father's supervision,respect) were negatively correlated with psychological symptom scores(path coefficient=-0.18,P＜0.05).Conclusion Family parenting styles can directly affect the psychological symptoms and the personality status,thereby affecting mental health of college students.Personality characteristics could be a mediated variable to regulate the relationship between family parenting styles and psychological health of college students.
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Objective To investigate error-related negativity characteristics of patients with internalizing mental disorders and its diagnostic value.Methods Fifty-five patients met with DSM-Ⅳ anxiety or depression criteria were sampled from outpatients and inpatients,and 20 normal adults were selected as control group.With Eriksen and Simon tasks as evoked stimuli,error-related negativities of each participant were acquired using Canada Stellate-64 channel EEG/ERP Instrument and BESA5.2 software,and the data of general information,clinical symptoms,reaction time,and error rate were collected.Results (1) Correct reaction time ((377.5±98.8) ms)and errors reaction time ((337.3±96.6)ms) of patient group were significantly longer than those of control group ((288.5±105.9)ms and (281.9±94.3)ms) on the Eriksen task and Simon task,and there were no significantly group differences on other indicators (P＞0.05).(2) ERN amplitudes at 6 sities (Fz =(4.97±5.74) μV,F3 =(5.50±4.59) μV,F4 =(6.26±6.79) μV,Cz =(4.74±5.51) μV,C3 =(5.44±4.8) μV,C4 =(5.50± 5.28) μV) of patients group were significantly greater than those of control group ((1.17± 1.47)μV,(2.22±3.95) μV,(3.40±2.55)μV,(2.28± 1.41) μV,(3.05±2.47) μV,(3.16±2.51) μV) on the Eriksen task.ERN amplitudes at Fz((5.43±6.61) μV) and F4((6.00±5.50)μV) of patient group were significantly were greater than those of control group ((2.05 ±2.34) μV,(3.09±2.86)μV) on the Simon task,and there were no significantly group differences on the ERN amplitudes at other sites (P＞0.05).(3) ERN latencies ((87.6±34.4) ms and (84.9±34.8) ms) of patient group at Fz and F4 were significantly longer than control group ((54.0±46.5) ms and (36.3±42.4)ms) on the Simon task,and there were no significantly group differences on the ERN latencies at other sites (P＞0.05).Conclusion The increased error related potentials suggest that patients with internalizing mental disorders has an internal error monitoring defects,and ERN might be a useful endophenotype for internalizing mental disorders.
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Objective To explore the association between the sortilin-related receptor,L (DLR class) A repeats containing (SORL1) gene single nucleotide polymorphisms (SNPs) and sporadic Alzheimer's disease (SAD) in Han Chinese populations.Methods Five candicate SNPs,including rs985421,rs12364988,rs4598682,rs3781834,and rs3781836,within the SORL1 gene were genotyped by LDR-PCR methods,and the association of these SNPs with SAD risk were also analyzed in a case-control study with 179 SAD and 106 healthy controls.Results The results indicated that the A allele frequency of the SORL1 SNP rs985421 was significant difference between SAD and healthy controls (Trend test:P =0.0044,P adj =0.022; Allelic:P=0.0023,P adj =0.012).In subjects without APOE s4 allele,higher frequency of the A allele of rs985421 was observed in SAD patients compared with control subjects by the stratified analysis (OR=2.260,95％ CI =1.269-4.024,P=0.0048).In addition,logistic regression analysis further revealed that the A allele of SORL1 SNP rs985421 was significantly associated with SAD risk (OR=1.968,95％ CI =1.273-3.042,P=0.002).However,no positive signals in other four SNPs within the SORL1 gene were observed (all P＞ 0.05).Conclusions The A allele of SORL1 SNP rs985421 may be an APOE ε4-independent factor associated with SAD risk.